Serostim is an injectable medication used to treat growth hormone deficiency in children and adults. It is available in vials and cartridges, and dosage and frequency are determined by the healthcare practitioner.

Composition:
Serostim contains somatropin, which is a synthetic version of the naturally occurring human growth hormone. It is manufactured using recombinant DNA technology to produce a version that is identical to the naturally occurring hormone.

Uses:
Serostim is indicated for the treatment of growth hormone deficiency in children and adults. It can also be used to treat muscle wasting associated with HIV/AIDS.

Usage and Dosage:
Serostim is administered by subcutaneous injection, with the dosage and frequency determined by the healthcare practitioner according to the patient’s age, weight, and condition. The recommended starting dose for children is up to 0.3 mg/kg per week, while the recommended dose for adults is up to 0.1 mg/kg per day. It is important not to exceed the prescribed dose, as this may result in adverse effects.

Storage Conditions:
Serostim should be refrigerated at temperatures between 2-8°C. It should be protected from light and stored in the original carton until use. Once reconstituted, Serostim should be used within 14 days and should not be frozen.

Mechanism of Action:
Serostim works by binding to specific receptors in the liver and other tissues in the body, stimulating the production of insulin-like growth factor 1 (IGF-1). IGF-1 promotes growth by stimulating the proliferation of chondrocytes (cartilage cells) and osteoblasts (bone-forming cells), as well as enhancing protein synthesis and reducing protein breakdown.

Contraindications:
Serostim should not be used in patients with a hypersensitivity to the active ingredient or any of the excipients used in the medication. It is also contraindicated in patients with active malignancy, as well as those with closed epiphyses (the end of long bones).

Interactions:
Serostim may interact with other medications that affect glucose homeostasis, such as glucocorticoids or insulin. Patients should inform their healthcare provider of any medications or supplements they are taking before using Serostim.

Side Effects:
Common side effects of Serostim include injection site reactions, headaches, joint pain, swelling, and muscle pain. Other potential side effects include carpal tunnel syndrome, insulin resistance, and increased risk for diabetes and cancer. Patients should seek medical attention immediately if any severe or persistent side effects are experienced.